RapamycinFungusV1, Main, Exploration, bibRecord, 000369

Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.

Identifieur interne : 000369 ( Main/Exploration ); précédent : 000368; suivant : 000370

Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.

Auteurs : Spandana Rajendra Kopalli [Corée du Sud] ; Kyu-Min Cha [Corée du Sud] ; Sang-Ho Lee [Corée du Sud] ; Seock-Yeon Hwang [Corée du Sud] ; Young-Joo Lee [Corée du Sud] ; Sushruta Koppula [Corée du Sud] ; Si-Kwan Kim [Corée du Sud]

Source :

Nutrients [ 2072-6643 ] ; 2019.

RBID : pubmed:31018574

Descripteurs français

KwdFr :
- ARN messager (MeSH), Animaux (MeSH), Complexe-1 cible mécanistique de la rapamycine (génétique), Complexe-1 cible mécanistique de la rapamycine (métabolisme), Cordyceps (composition chimique), Désoxyadénosine (administration et posologie), Désoxyadénosine (pharmacologie), Facteurs de transcription (génétique), Facteurs de transcription (métabolisme), Mâle (MeSH), Rat Sprague-Dawley (MeSH), Rats (MeSH), Récepteur FSH (génétique), Récepteur FSH (métabolisme), Récepteur LH (génétique), Récepteur LH (métabolisme), Récepteurs aux androgènes (génétique), Récepteurs aux androgènes (métabolisme), Régulation de l'expression des gènes (effets des médicaments et des substances chimiques), Sirtuine-1 (génétique), Sirtuine-1 (métabolisme), Spermatogenèse (MeSH), Testicule (effets des médicaments et des substances chimiques), Vieillissement (MeSH).
MESH :
- administration et posologie : Désoxyadénosine.
- composition chimique : Cordyceps.
- effets des médicaments et des substances chimiques : Régulation de l'expression des gènes, Testicule.
- génétique : Complexe-1 cible mécanistique de la rapamycine, Facteurs de transcription, Récepteur FSH, Récepteur LH, Récepteurs aux androgènes, Sirtuine-1.
- métabolisme : Complexe-1 cible mécanistique de la rapamycine, Facteurs de transcription, Récepteur FSH, Récepteur LH, Récepteurs aux androgènes, Sirtuine-1.
- pharmacologie : Désoxyadénosine.
- ARN messager, Animaux, Mâle, Rat Sprague-Dawley, Rats, Spermatogenèse, Vieillissement.

English descriptors

KwdEn :
- Aging (MeSH), Animals (MeSH), Cordyceps (chemistry), Deoxyadenosines (administration & dosage), Deoxyadenosines (pharmacology), Gene Expression Regulation (drug effects), Male (MeSH), Mechanistic Target of Rapamycin Complex 1 (genetics), Mechanistic Target of Rapamycin Complex 1 (metabolism), RNA, Messenger (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Receptors, Androgen (genetics), Receptors, Androgen (metabolism), Receptors, FSH (genetics), Receptors, FSH (metabolism), Receptors, LH (genetics), Receptors, LH (metabolism), Sirtuin 1 (genetics), Sirtuin 1 (metabolism), Spermatogenesis (MeSH), Testis (drug effects), Transcription Factors (genetics), Transcription Factors (metabolism).
MESH :
- chemical , administration & dosage : Deoxyadenosines.
- chemistry : Cordyceps.
- drug effects : Gene Expression Regulation, Testis.
- chemical , genetics : Mechanistic Target of Rapamycin Complex 1, Receptors, Androgen, Receptors, FSH, Receptors, LH, Sirtuin 1, Transcription Factors.
- chemical , metabolism : Mechanistic Target of Rapamycin Complex 1, Receptors, Androgen, Receptors, FSH, Receptors, LH, Sirtuin 1, Transcription Factors.
- chemical , pharmacology : Deoxyadenosines.
- Aging, Animals, Male, RNA, Messenger, Rats, Rats, Sprague-Dawley, Spermatogenesis.

Abstract

Age-related male sexual dysfunction covers a wide variety of issues, together with spermatogenic and testicular impairment. In the present work, the effects of cordycepin (COR), an active constituent of a nutrient powerhouse Cordyceps militaris Linn, on senile testicular dysfunction in rats was investigated. The sperm kinematics, antioxidant enzymes, spermatogenic factors, sex hormone receptors, histone deacetylating sirtuin 1 (SIRT1), and autophagy-related mammalian target of rapamycin complex 1 (mTORC1) expression in aged rat testes were evaluated. Sprague Dawley rats were divided into young control (2-month-old; YC), aged control (12-month-old; AC), and aged plus COR-treated groups (5 (COR-5), 10 (COR-10), and 20 (COR-20) mg/kg). The AC group showed reduced sperm kinematics and altered testicular histomorphology compared with the YC group (p < 0.05). However, compared with the AC group, the COR-treated group exhibited improved sperm motility, progressiveness, and average path/straight line velocity (p < 0.05-0.01). Alterations in spermatogenesis-related protein and mRNA expression were significantly ameliorated (p < 0.05) in the COR-20 group compared with the AC group. The altered histone deacetylating SIRT1 and autophagy-related mTORC1 molecular expression in aged rats were restored in the COR-20 group (p < 0.05). In conclusion, the results suggest that COR holds immense nutritional potential and therapeutic value in ameliorating age-related male sexual dysfunctions.

DOI: 10.3390/nu11040906
PubMed: 31018574
PubMed Central: PMC6520895

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000286
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Le document en format XML

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 Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.</title>
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 Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.</title>
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<series><title level="j">Nutrients</title>
<idno type="eISSN">2072-6643</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Cordyceps (chemistry)</term>
<term>Deoxyadenosines (administration & dosage)</term>
<term>Deoxyadenosines (pharmacology)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Male (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term>
<term>RNA, Messenger (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Rats, Sprague-Dawley (MeSH)</term>
<term>Receptors, Androgen (genetics)</term>
<term>Receptors, Androgen (metabolism)</term>
<term>Receptors, FSH (genetics)</term>
<term>Receptors, FSH (metabolism)</term>
<term>Receptors, LH (genetics)</term>
<term>Receptors, LH (metabolism)</term>
<term>Sirtuin 1 (genetics)</term>
<term>Sirtuin 1 (metabolism)</term>
<term>Spermatogenesis (MeSH)</term>
<term>Testis (drug effects)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (génétique)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Cordyceps (composition chimique)</term>
<term>Désoxyadénosine (administration et posologie)</term>
<term>Désoxyadénosine (pharmacologie)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Mâle (MeSH)</term>
<term>Rat Sprague-Dawley (MeSH)</term>
<term>Rats (MeSH)</term>
<term>Récepteur FSH (génétique)</term>
<term>Récepteur FSH (métabolisme)</term>
<term>Récepteur LH (génétique)</term>
<term>Récepteur LH (métabolisme)</term>
<term>Récepteurs aux androgènes (génétique)</term>
<term>Récepteurs aux androgènes (métabolisme)</term>
<term>Régulation de l'expression des gènes (effets des médicaments et des substances chimiques)</term>
<term>Sirtuine-1 (génétique)</term>
<term>Sirtuine-1 (métabolisme)</term>
<term>Spermatogenèse (MeSH)</term>
<term>Testicule (effets des médicaments et des substances chimiques)</term>
<term>Vieillissement (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Deoxyadenosines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Désoxyadénosine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cordyceps</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Cordyceps</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term>
<term>Testis</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Régulation de l'expression des gènes</term>
<term>Testicule</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Receptors, Androgen</term>
<term>Receptors, FSH</term>
<term>Receptors, LH</term>
<term>Sirtuin 1</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Facteurs de transcription</term>
<term>Récepteur FSH</term>
<term>Récepteur LH</term>
<term>Récepteurs aux androgènes</term>
<term>Sirtuine-1</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Receptors, Androgen</term>
<term>Receptors, FSH</term>
<term>Receptors, LH</term>
<term>Sirtuin 1</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Facteurs de transcription</term>
<term>Récepteur FSH</term>
<term>Récepteur LH</term>
<term>Récepteurs aux androgènes</term>
<term>Sirtuine-1</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Désoxyadénosine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Deoxyadenosines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aging</term>
<term>Animals</term>
<term>Male</term>
<term>RNA, Messenger</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Spermatogenesis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ARN messager</term>
<term>Animaux</term>
<term>Mâle</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Spermatogenèse</term>
<term>Vieillissement</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Age-related male sexual dysfunction covers a wide variety of issues, together with spermatogenic and testicular impairment. In the present work, the effects of cordycepin (COR), an active constituent of a nutrient powerhouse <i>Cordyceps militaris</i>
 Linn, on senile testicular dysfunction in rats was investigated. The sperm kinematics, antioxidant enzymes, spermatogenic factors, sex hormone receptors, histone deacetylating sirtuin 1 (SIRT1), and autophagy-related mammalian target of rapamycin complex 1 (mTORC1) expression in aged rat testes were evaluated. Sprague Dawley rats were divided into young control (2-month-old; YC), aged control (12-month-old; AC), and aged plus COR-treated groups (5 (COR-5), 10 (COR-10), and 20 (COR-20) mg/kg). The AC group showed reduced sperm kinematics and altered testicular histomorphology compared with the YC group (<i>p</i>
 < 0.05). However, compared with the AC group, the COR-treated group exhibited improved sperm motility, progressiveness, and average path/straight line velocity (<i>p</i>
 < 0.05-0.01). Alterations in spermatogenesis-related protein and mRNA expression were significantly ameliorated (<i>p</i>
 < 0.05) in the COR-20 group compared with the AC group. The altered histone deacetylating SIRT1 and autophagy-related mTORC1 molecular expression in aged rats were restored in the COR-20 group (<i>p</i>
 < 0.05). In conclusion, the results suggest that COR holds immense nutritional potential and therapeutic value in ameliorating age-related male sexual dysfunctions.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31018574</PMID>
<DateCompleted><Year>2019</Year>
<Month>11</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2072-6643</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>4</Issue>
<PubDate><Year>2019</Year>
<Month>Apr</Month>
<Day>23</Day>
</PubDate>
</JournalIssue>
<Title>Nutrients</Title>
<ISOAbbreviation>Nutrients</ISOAbbreviation>
</Journal>
<ArticleTitle>Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom <i>Cordyceps militaris</i>
 Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E906</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/nu11040906</ELocationID>
<Abstract><AbstractText>Age-related male sexual dysfunction covers a wide variety of issues, together with spermatogenic and testicular impairment. In the present work, the effects of cordycepin (COR), an active constituent of a nutrient powerhouse <i>Cordyceps militaris</i>
 Linn, on senile testicular dysfunction in rats was investigated. The sperm kinematics, antioxidant enzymes, spermatogenic factors, sex hormone receptors, histone deacetylating sirtuin 1 (SIRT1), and autophagy-related mammalian target of rapamycin complex 1 (mTORC1) expression in aged rat testes were evaluated. Sprague Dawley rats were divided into young control (2-month-old; YC), aged control (12-month-old; AC), and aged plus COR-treated groups (5 (COR-5), 10 (COR-10), and 20 (COR-20) mg/kg). The AC group showed reduced sperm kinematics and altered testicular histomorphology compared with the YC group (<i>p</i>
 < 0.05). However, compared with the AC group, the COR-treated group exhibited improved sperm motility, progressiveness, and average path/straight line velocity (<i>p</i>
 < 0.05-0.01). Alterations in spermatogenesis-related protein and mRNA expression were significantly ameliorated (<i>p</i>
 < 0.05) in the COR-20 group compared with the AC group. The altered histone deacetylating SIRT1 and autophagy-related mTORC1 molecular expression in aged rats were restored in the COR-20 group (<i>p</i>
 < 0.05). In conclusion, the results suggest that COR holds immense nutritional potential and therapeutic value in ameliorating age-related male sexual dysfunctions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kopalli</LastName>
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	Serveur d'exploration sur la rapamycine et les champignons
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Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.

Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.

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